Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Abstract Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions.Studies of motif-mediated interactions therefore provide insight into virus-host dependencies, and reveal targets for therapeutic intervention.Here, we describe the Leggings pan-viral discovery of 1712 SLiM-based virus-host interactions using a phage